There are many growth factors that are found in your blood and concentrated to form Platelet Rich Plasma (PRP). These growth factors function to stimulate the healing process inside of your own body to super high levels. They begin to do things like make new blood vessels and grow new tissue. This massive stimulation your body receives allows your body to heal from things such as alopecia, wrinkling skin, degenerating joints and many other ailments your body begins to develop.
These growth factors are too complicated to go into depth on each one in one blog article. So we will briefly summarize their functions here today and future blog articles will follow going over each one in more detail. It is important to remember that how highly concentrated we can get these growth factors, affects how much healing potential we can achieve. At Littleton PRP we make sure to use the highest quality equipment to achieve 8-10 times the normal concentrations found in your blood.
I will briefly summarize each growth factors’ functions. The growth factors found in PRP include the following:
PDGF (Platelet-derived Growth Factor)
PDGF has the job of regulating cell growth and division. PDGF is also “a required element in cellular division for fibroblasts, a type of connective tissue cell that is especially prevalent in wound healing.”
VEGF (Vascular Endothelial Growth Factor)
VEGF is a signaling protein that has the job angiogenesis (forming new blood vessels from existing ones). “VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, [new] muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.”
TGF- 1 (Transforming Growth Factor Beta-1)
TGF - 1 has the job of controlling cell growth, proliferation and differentiation as well as apoptosis (programmed cell death).
EGF (Epidermal Growth Factor)
“EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface. This stimulates......a signal transduction cascade that results in a variety of biochemical changes within the cell – a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR – that ultimately lead to DNA synthesis and cell proliferation.” In short, EGF starts a process that ends creation of new DNA and new cells!
bFGF (basic Fibroblast Growth Factor)
bFGF “...is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state…”
IGF-1 (Insulin-like Growth Factor-1)
IGF-1 “...plays an important role in childhood growth and continues to have anabolic effects in adults.” This helps you grow as a child and as an adult. Anabolic means building up, such as building muscle tissue after working out.
HGF (Hepatocyte Growth Factor)
HGF regulates cell growth, movement and change into new cells. “It has been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration, and in wound healing.”
Hopefully having this basic understanding of each growth factor will help you see the healing potential that PRP has! And remember that these are all found within your own blood. So the procedure is incredibly safe and effective. Call us today to have your joint of concern examined and to have your PRP procedure scheduled today!